Products Description
English name：Dalbavancin hydrochloride
CAS number：2227366-51-8
Molecular formula：C88H101Cl3N10O28
Molecular weight：1853.15
EINECS No:
Related categories: Pharmaceutical raw materials
The Mol file:2227366-51-8.mol
Structural formula:
DabwanStar hydrochloride properties
Storage conditions: underinertgas (nitrogenorArgon) at2-8 C
Solubility: dimethylChemicalbook sulfone: 24mg/mL(12.95mM)
Form: solid
Color: White to light yellow water
Solubility: Water:50mg/mL(26.98mM)
DabwanStar hydrochloride, use and synthesis method
Bioactivity
Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semi-synthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride The MIC90 against S. aureus and B. anthracis were 0.06 μg/mL and 0.25 μ g / mL, respectively.
In vitro study
Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including S. aureus (MRSA), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and β-hemolytic streptococci , organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.
In vivo
Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.
Animal Model: Female BALB/c mice (6-8 weeks) challenged with Ames strain of B. anthracis
Dosage: 15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
Administration: Intraperitoneal injection; every 36 h or 72 h; for 14 days
Result: The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.
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