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Val-Cit-PAB-MMAE Is An Antibody Drug Conjugator Inhibitor

Val-Cit-PAB-MMAE Is An Antibody Drug Conjugator Inhibitor

English name：Val-Cit-PAB-MMAE
CAS number：644981-35-1
Another name:
Val-Cit-PAB-MMAE;4H-1-Benzopyran-4-one,7-hydroxy-4-(trifluoromethyl)-;Drug-Linker Conjugates for ADC,inhibit,Inhibitor,Val Cit PAB MMAE,ValCitPABMMAE;4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate;VCPMMAE;Val-Cit-PAB-MMAE, 10 mM in DMSO
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Products Description

 

English name：Val-Cit-PAB-MMAE

CAS number：644981-35-1

Molecular formula: C58H94N10O12

Molecular weight: 1123.42676

EINECS No.:

Related categories: Amino acid derivatives; pharmaceutical raw materials; biological reagents; ADCs

The Mol file: 644981-35-1.mol

 

Structural formula:

1 -

 

The VAL-CIT-PAB-OH properties

Solubility: dissolved in dichloromethane

Form: solid

Color: white to off-white

InChIKey:WZEAGSMYTVSXQA-DQTLHWFHNA-N

 

Use and synthesis method of VAL-CIT-PAB-OH

 

Bioactivity

Val-Cit-PAB-MMAE is part of the antibody-conjugated drug ADC, conjugated to ADC linker (peptide Val-Cit-PAB) and the potent tubulin inhibitor MMAE (HY-15162).

 

Target site

Auristatin

 

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