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Duocarmycin SA Oral Active Antitumor Antibiotic

Duocarmycin SA Oral Active Antitumor Antibiotic

English name：Duocarmycin SA
CAS number：130288-24-3
English synonym：
Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylicacid,1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-,methylester,(7bR,8aS)-;DuocarmycinSA;Cyclopropacpyrrolo3,2-eindole-6-carboxylicacid,1,2,4,5,8,8a-hexahydroChemicalbook-4-oxo-2-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-,methylester,(7bR)-;AntibioticDC113;CS-1375;methyl(1R,12S)-7-oxo-10-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-5,10-diazatetracyclo[7.4.0.01,12.02,?]trideca-2(6),3,8-triene-4-carboxylate
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Products Description

 

English name：Duocarmycin SA

CAS number：130288-24-3

Molecular formulaC25H23N3O7

Molecular weight 477.47

 

Molecular structure:

2 -

 

Related categories of pharmaceutical raw materials

 

Duocarmycin SA properties

 

Boiling point 787.7±60.0 °C(Predicted)

Density 1.53± 0.1g /cm3(Predicted)

Morphological solid

Acidity coefficient (pKa)13.12±0.20(Predicted)

Color beige white to light yellow

 

The use and synthesis method of duocamycin SA

 

DuocarmycinSA is a potent anti-tumor antibiotic with an IC50 of 10pM. DuocarmycinSA is a highly potent cytotoxic agent capable of inducing sequence-selective alkylation of double-stranded DChemicalbookNA. DuocarmycinSA demonstrated synergistic cytotoxicity to glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.
Target point
Duocarmycins

 

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