DM4 Inhibitor Antibody Drug Conjugate

English name：DM4
CAS number：796073-69-3
Another name:
N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine;Maytansine,N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-;DM4top3;MertansinChemicalbookeImpurity1;N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine(DM4);TheelementDM4;Benzoicacid,5-(chlorosulfonyl)-4-methyl-;Ravtansine

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Products Description

English name：DM4

CAS number：796073-69-3

Molecular formula: C38H54ClN3O10S

Molecular weight: 780.37

EINECS No.:

Related categories

Pharmaceutical raw materials; pharmaceutical raw materials; pharmaceutical API research raw materials; medical raw materials; active small molecule library; anti-tumor; reagent; chemical reagent

The Mol file: 796073-69-3.mol

Structural formula:

N2 ′ -deacetyl-N2 ′ - (4-sulfhydryl-4-methyl-1-oxyopentyl) -Mendenin properties

Melting point: 185-187 C (decomp)

Boiling point; 943.2 ± 65.0 C (Predicted)

Density: 1.29±0.1g/cm3 (Predicted)

Storage conditions: StoChemicalbookreat-20 C

Solubility: dimethyl sulfoxide: 100mg/mL(128.14mM)

Aciity coefficient (pK a): 9.82 ± 0.70 (Predicted)

Form: solid

Color: White to light yellow

N2 ′ -deacetyl-N2 ′ - (4-sulfhydryl-4-methyl-1-oxyopentyl) -MMD

Cytotoxin

DM4 is an anti-microtubule egg agent that suppresses cell division. DM4 can be used to prepare antibody drug conjugates. Medin (Mertansine, DM1, CAS: 796073-69-3) is a microtubule Chemicalbook protein inhibitor that binds to the ends of microtubules and suppresses microtubule dynamics. Mertansine Is an antibody-conjugated medin alkaloid used to overcome systemic toxicity associated with medin and enhance tumor-specific delivery.

Bioactivity

DM4 is an anti-microtubule egg agent that suppresses cell division. DM4 can be used to prepare antibody drug conjugates.

In vitro study

DM4,astructuralanalogueofmaytansine,isanewthiol-containingandpotentmaytansinoid.DM4isacytotoxicmaytansinoiddrug.Itissynthesizedinordertolinkmaytansinoidstoantibodiesviadisulfidebonds.MaytansinoChemicalbookidsinhibittubulinpolymerizationandmicrotubuleassemblyandenhancemicrotubuledestabilization,sothereispotentsuppressionofmicrotubuledynamicsresultinginamitoticblockandsubsequentapoptoticcelldeath.

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