Products Description
English name：Trastuzumab Deruxtecan
CAS number：1826843-81-5
molecular formula:
Molecular weight: 0
EINECS No.:
Related categories: Pharmaceutical raw materials
The Mol file: Mol File
constitutional formula:
Trastuzumab Deruxtecan Nature
Storage conditions: Solution, -20 C, 2 years
Dissolution: degrees dissolve in acetonitrile
Form: solid
Color: white to off-white
Trastuzumab Deruxtecan Use and synthesis method
Bioactivity
Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER 2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan Composed of a humanized anti-HER 2 antibody, a peptide adaptor for enzymatic cleavage, and a topoisomerase I inhibitor. Trastuzumab deruxtecan Can be used to study HER 2-positive breast cancer and gastric cancer.
In vitro study
Trastuzumabderuxtecan(1pM-10nM;5days)inhibitsthegrowthofHER2‐positiveKPL‐4cells,withanIC50of109.7pM.TrastChemicalbookuzumabderuxtecan(10nM;5days)showsbystanderkillingeffectsinHER2‐negativeMDA‐MB‐468cells.CellViabilityAssay
Cell Line: KPL‐4 and MDA‐MB‐468 cells
Concentration: 1, 10, 100, 1000, 10000 pM
Incubation Time: 5 days
Result: Killed both HER2‐positive KPL‐4 cells and HER2‐negative MDA‐MB‐468 cells.
In vivo research
Trastuzumab deruxtecan (3 mg/kg; a single i.v.) shows antitumor activity against not only HER2‐positive tumors but also HER2‐negative tumors under the co‐inoculated condition.
Trastuzumab deruxtecan (10 mg/kg; i.v. on days 0 and 7) inhibits the tumor growth in in EMT6-hHER2 syngeneic mouse model.
AnimalModel:FemaleBALB/cnudemiceinjectedwithNCI‐N87andMDA‐MB‐468‐Luc cells
Dosage:3mg/kg
Administration:Asinglei.v
Almost all of the HER2‐positive and HER‐negative cells disappeared and there were little or no cancer cells
Result:
remaining in the tumors.
Security information
MSDS information
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