Nystatin Is An Antifungal Agent

English name：Nystatin

CAS number：1400-61-9

Molecular formula: C47H75NO17

Molecular weight: 926.09

EINECS number: 215-749-0

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Mol file：1400-61-9.mol

Structural formula:

Nystatin properties

Melting point: >155°C(dec.)

Specific rotation: D25-10°(glacialaceticacid); +21°(pyridine); +12°(DMF); 7 ° NHClinmethanol (0.1)

Storage condition: -20°C

Solubility: Insoluble in water

Acidity coefficient (pKa) : pKaChemicalbook5.72(MeOH/2-methoxyethanol/H2O)(Uncertain); 8.64 (all)

Form: suspension

Color: Sticky yellow

Odor: odor of grain

Biological source: Streptomycesnoursei

Water solubility: 0.36g/L(24ºC)

Merck：13,6770

Specific Activity：≥4,400USP units/mg

BCS Class：3

InChIKey：VXWFKTGGEJLHPP-OQMKPJEFSA-N

CAS database: 1400-61-9EPA

Chemical Information: Nystatin (1400-61-9)

Polyene antifungins

Nystatin is a kind of polyene antifungicin with conjugated polyene macrolide structure, which can inhibit the activity of fungi, but can be used for Chemicalbook without inhibition to bacteria. Nystatin binds to sterols on fungal cell membranes and causes changes in cell membrane permeability, resulting in leakage of important cell contents and plays an antifungal role.

Nystatin has many applications, such as preventing cell culture contamination and inducing interleukin (IL) -, IL-8, TLR2 to express ThP1-secreted cell tumor-bad Chemicalbook death factor-α. Nystatin is used as a fungal membrane (ergosterol binding) pore-making agent and to create nystatin/p-ergosterol ion channels in the lipid bilayer.

Nystatin, as a fungal inhibitor, is often used to prepare selective media.

Nystatin can be used in cell culture with a recommended working concentration of 0.05mg/ml. It has effective inhibition effect and is stable at 37℃ for 3 days. 50mg/ml suspension can be prepared as storage solution and stored at -20℃. High pressure or filtration is not recommended.

Antibacterial spectrum

Nystatin has strong antibacterial activity against Candida, Cryptococcus neoformans, Aspergillus, trichophyton, coccidioides, histoplasma capsulatus, blastomyces dermatitis, dermatophyton and so on.

Physical and chemical properties

Yellow or yellowish brown powder, with special odor and moisture-inducing properties. Slightly soluble in water, methanol, ethanol, insoluble in acetone, ether and chloroform. Nystatin is unstable to air, light, heat, water, acid or base.

Action mechanism

Nystatin can bind to sterols on the fungal cell membrane, so that the permeability of the cell membrane changes, resulting in the leakage of important intracellular substances, so as to play an antifungal role.

Apply

Nystatin, also known as nystatin, micodin, is an antifungal drug, Candida albicans, cryptococcus neoformans, Aspergillus, mucor and microspora are sensitive to this drug, it is recommended to follow the doctor's advice to use the drug.

pharmacokinetics

Nystatin is not absorbed by gastrointestinal tract after oral administration, and is not absorbed by skin and mucosa for local topical use. Almost the entire dose is excreted from the stool in its original form. Local administration of the drug for the treatment of candidiasis, 24 to 72 hours after the maximum effect.

Use

Nystatin tablets have a broad spectrum of antifungal activity, and the bacterial spectrum and antibacterial mechanism are similar to amphotericin B. They have high antibacterial activity against Candida, Cryptococcus neoformans, Aspergillus Chemicalbook, mucor, microspora, histoplasma capsulatus, Blastomyces dermatitis and dermatophyton. They are mainly used for candida albicans infection of skin mucosa, mouth and vagina.

Chemical property

Yellow or yellowish brown powder, with special odor and moisture-inducing properties. Slightly soluble in water, methanol, ethanol, insoluble in acetone, ether and chloroform. It is unstable to air, light, heat, water, acid or alkali. Antifungal antibiotics.

Use

Nystatin is a polyene antifungal antibiotic with powerful pro-inflammatory properties. It has many applications, such as preventing cell culture contamination and inducing the expression of ThP1-secreted cell tumor necrosis factor-α by interleukin (IL) -, IL-8, TLR2Chemicalbook. It is used as a fungal membrane (ergosterol binding) pore-making agent and to create nystatin/p-ergosterol ion channels in the lipid bilayer.

A polyene antifungal drug containing three bioactive ingredients: A1, A2, and A3, with powerful pro-inflammatory properties. It is mainly used for candida albicans infection of skin mucosa, mouth, intestine and vagina, and has bactericidal effect in high concentration.

Safety information

Dangerous Goods Mark: F,C

Danger category code: 11-34

Safety Instructions: 22-24/25-45-36/37/39-26-16

WGK Germany：3

The RTECS：RF5950000

F : 10-8-23

Danger class：3

Customs Code: 38210000

Hazardous Substances Data: 1400-61-9(Hazardous Substances Data)

Toxicity: LD50 i.p. in mice: ~200 mg/kg (Seneca)

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