Semaglutide Side Chain

English name：Semaglutide side chain

CAS number：1118767-16-0

Molecular formula：C43H79N3O13

Molecular weight :846.1

Related :Impurities; special amino acids; sommarlutide; pharmaceutical peptides; amino acid derivatives; raw materials; sommarlutide intermediates; sommarlutide

Constitutional formula:

Boiling point :940.6±65.0 °C(Predicted)

Density :1.079±0.06 g/cm3(Predicted)

condition of storage: Keep in dark place, Sealed in dry, Store in freezer, under -20°C

Aciity 3.39±0.10(Predicted)

InChIKey:YZUXNRZPWYRMGH-DHUJRADRSA-N

SMILES:C(O)(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](C(OC(C)(C)C)=O)NC(=O)CCCCCCCCCCCCCCCCC(OC(C)(C)C)=O

Receptor agonist

Sommarlutide is a novel glucagon-like peptide-1 (GLP-1) receptor agonist, and its side chain structure is key to its uniqueness. The somallutide side chain consists of a series of amino acids in which alanine is its essential component. The structure of alanine contains a chiral center with two Chemicalbook configurations left and right handed. Somaglutide employs an advanced technique that makes the drug contains only one configuration of alanine, thus greatly improving drug purity and therapeutic efficacy. In addition, the somaglutide side chain can also be modified to multiple chemical modifications to change its biological activity and pharmacokinetic properties, providing more possibilities for the treatment of diabetes.

Pharmacological action

The somaglutide side chain exerts its pharmacological effects through the activation of the GLP-1 receptor. GLP-1 is a hormone secreted by intestinal L cells to promote insulin secretion and inhibit glucagon secretion, thereby reducing blood glucose levels. After binding to the GLP-Chemicalbook1 receptor with the somaglutide side chain, it is able to mimic the biological activity of GLP-1, promote insulin secretion and inhibit glucagon secretion, and subsequently reduce blood glucose levels. In addition, the somallutide side chain can also inhibit appetite and slow down the gastric emptying rate, helping to control body weight and improve metabolic status.

Clinical use

Somaglutide side chain, as a novel diabetes treatment drug, has been widely used in clinical practice. In addition, somlutide side chain also has the effect of weight loss and cardiovascular risk, bringing more health benefits to patients with diabetes.

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