Products Description
English name：Pneumocandin B0
CAS number：135575-42-7
Molecular formula：C50H80N8O17
Molecular weight :1065.21
EINECS：629-746-0
Related :Antifungal class; raw material; Microbial metabolites; Caspofungin intermediate; Medical intermediates; anti-infection; acridine; materia medica; additive; Control article-Chinese medicine control; Antifungals; ChiralReagents; Heterocycles; IntChemicalbookermediates&FineChemicals; Pharmaceuticals; API; OtherAPIs; crude drug; raw material; antibacterial; antiviral; chemicals; Drug substance and intermediates; Daily-use chemicals; antibiosis; organic chemical industry; chemical reagent
Constitutional formul:
Pneumocandin B0 properties
Melting point:：>230°C (dec.)
Boiling point: 1442.9±65.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
condition of storage: Sealed in dry,Store in freezer, under -20°C
Solubility: Solsoluble in DMSO (small), methanol (small)
Form: solid
Aciity coefficient: 9.86±0.26(Predicted)
Color: White to almost white
Max wavelength (λ max):276nm(MeOH)(lit.)
InChIKey:DQXPFAADCTZLNL-PYWTXGKPNA-N
Use and synthesis methods
Introduction
Numocontin (Pneumocandins) B0 is a natural antifungal drug produced by Zalerionarboricola, with cyclic hexapeptide parent nucleus and fatty acid side chain structure, because it attracts more and more attention to many kinds of Candida Chemicalbook, endemic fungi, Aspergillus and C. The cyclic hexapeptide parent core after the removal of the fatty acid side chain of Numocondine B0 is the main raw material for the synthesis of caspofungin (Caspofungin).
Mechanism of action
Numocondine B0 is an antifungal lipopeptide, a potent antifungal agent that acts by inhibiting β - (1,3) -D-glucan, an essential component of the sensitive fungal cell wall. It acts by inhibiting the synthesis of β - (1,3) -ChemicalbookD-glucan (a component of the fungal cell wall) (IC50=70 and 67 ng/ml for the inhibition of glucan synthase and A1 in Candida albicans) and can be used for the synthesis of caspofungin acetate.
Use
Numoconine B0 can be used as a scientific reagent, widely used in molecular biology, pharmacology and other scientific aspects.
bioactivity
Pneumocandin B0 (L-688786) is the synthetic intermediate of Cancidas.
Chemical properties：
white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
Customs code: 2941.90.3000
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